Optimal Experimental Design for Parameter Estimation of a Cell Signaling Model
نویسندگان
چکیده
منابع مشابه
Optimal Experimental Design for Parameter Estimation of a Cell Signaling Model
Differential equation models that describe the dynamic changes of biochemical signaling states are important tools to understand cellular behavior. An essential task in building such representations is to infer the affinities, rate constants, and other parameters of a model from actual measurement data. However, intuitive measurement protocols often fail to generate data that restrict the range...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2009
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000558